Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies (Details)

v3.21.2
Commitments and Contingencies (Details)
€ in Millions
1 Months Ended 3 Months Ended 9 Months Ended
Mar. 01, 2020
Jul. 05, 2019
Nov. 16, 2018
Aug. 20, 2021
USD ($)
Mar. 24, 2021
USD ($)
Jan. 26, 2021
Dec. 31, 2020
USD ($)
Mar. 24, 2019
Oct. 31, 2018
Sep. 30, 2021
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2021
EUR (€)
Sep. 30, 2020
USD ($)
Aug. 17, 2021
Commitments and Contingencies (Details) [Line Items]                            
License fees and milestone payments, description                     the Company paid UVA LVG a license issue fee and is obligated to pay UVA LVG (i) annual minimum royalties of $40,000 commencing in 2017; (ii) a $20,000 milestone payments upon dosing the first patient under a Phase 3 human clinical trial of a licensed product, $155,000 upon the earlier of the completion of a Phase 3 trial of a licensed product, partnering of a licensed product, or sale of the Company, $275,000 upon acceptance of an NDA by the FDA, and $1,000,000 upon approval for sale of AD04 in the U.S., Europe or Japan; as well as (iii) royalties equal to a 2% and 1% of net sales of licensed products in countries in which a valid patent exists or does not exist, respectively, with royalties paid quarterly. In the event of a sublicense to a third party, the Company is obligated to pay royalties to UVA LVG equal to a percentage of what the Company would have been required to pay to UVA LVG had it sold the products under sublicense ourselves. In addition, the Company is required to pay to UVA LVG 15% of any sublicensing income. the Company paid UVA LVG a license issue fee and is obligated to pay UVA LVG (i) annual minimum royalties of $40,000 commencing in 2017; (ii) a $20,000 milestone payments upon dosing the first patient under a Phase 3 human clinical trial of a licensed product, $155,000 upon the earlier of the completion of a Phase 3 trial of a licensed product, partnering of a licensed product, or sale of the Company, $275,000 upon acceptance of an NDA by the FDA, and $1,000,000 upon approval for sale of AD04 in the U.S., Europe or Japan; as well as (iii) royalties equal to a 2% and 1% of net sales of licensed products in countries in which a valid patent exists or does not exist, respectively, with royalties paid quarterly. In the event of a sublicense to a third party, the Company is obligated to pay royalties to UVA LVG equal to a percentage of what the Company would have been required to pay to UVA LVG had it sold the products under sublicense ourselves. In addition, the Company is required to pay to UVA LVG 15% of any sublicensing income.    
Minimum license royalty expenses                   $ 10,000 $ 30,000      
Master services agreement, description   the MSA will total approximately $300,000, of which shares of the Company’s common stock having a value equal to twenty percent (20%) of this total can be issued to Dr. Johnson in lieu of cash payment.As of September 30, 2021, the Company had recognized $181,495 in expenses, of which $108,056 were charged against cash advanced under the terms of the Amendment, leaving a net prepaid expense asset of $111,767 associated with this vendor agreement. On April 5, 2021, the Company entered into another Lock-Up Agreement Extension (the “Second Lock-Up Extension”), which amended the Lock-Up Extension and extended the term of Dr. Johnson’s Lock-Up from April 1, 2021 until such date as the Company shall have publicly released the data from its ONWARD™ Phase 3 pivotal trial of its lead drug candidate, AD04, in genetically identified subjects for the treatment of Alcohol Use Disorder.             The MSA has a term of five years, automatically renewed for two-year periods, unless either party gives written notice of a decision not to renew the agreement six months prior to automatic renewal.          
Service agreement, description     the MSA for a 24 week, multi-centered, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 clinical study of the Company’s lead compound, AD04 for fees, as amended, of $3,649,933 (€3,168,895 converted to dollars at the Euro/US Dollar exchange rate of 1.1518 as of September 30, 2021) milestone payments. Through the end of 2020, 60% of the fee, a total of €1,619,626 in milestones, had been paid.                      
Prepaid expenses                     2,500   $ (322,507)  
Costs associated amount                   366,452 $ 1,918,604      
Operating lease remaining lease description                     The Company has one operating lease which consists of office space with a remaining lease term of approximately five years.  The Company has one operating lease which consists of office space with a remaining lease term of approximately five years.     
Estimated incremental borrowing rate           9.00%                
Future lease payments included in the measurement of lease liabilities                     5 years 5 years    
Lease commitments related party, description the Company entered into a sublease with Purnovate, LLC, a private company in which the Company’s CEO had a 28.7% equity interest, for the lease of three offices at 1180 Seminole Trail, Suite 495, Charlottesville, VA 22901. The lease had a term of two years, and the monthly rent was $1,400. During the nine months ended September 30, 2021, the rent expense associated with this lease was $1,400. On acquisition of Purnovate, the sublease was terminated and the Company assumed the obligations of Purnovate’s lease.                          
Consulting agreement term               3 years            
Consulting agreement, description               Johnson’s annual fee of $375,000 per year is paid twice per month. On execution, Dr. Johnson received a signing bonus of $250,000 and option to purchase 250,000 shares of common stock. Dr. Johnson’s participation in the Grant Incentive Plan (see below) and 2017 Equity Incentive Plan continue unaffected. The Company recognized $93,750 and $281,250 in compensation expense, respectively, in the both the three and nine months ended September 30, 2021 and 2020 as a result of this agreement.            
Future cash                   $ 1,200,000 $ 1,200,000      
Sixth Milestone [Member]                            
Commitments and Contingencies (Details) [Line Items]                            
Sites, percent         60.00%                  
Prepaid expenses         $ 318,905                  
Seventh Milestone [Member]                            
Commitments and Contingencies (Details) [Line Items]                            
Sites, percent                           100.00%
Prepaid expenses       $ 317,042                    
Service Agreement 1 [Member]                            
Commitments and Contingencies (Details) [Line Items]                            
Direct expenses                     1,249,547      
Accrued R&D expenses             $ 53,065              
Accrued expense liability                     575,572      
Estimated cost                     2,500,000 € 2.2    
Estimated future site costs                     $ 3,000,000